Plumbagin Protects Mice from Lethal Sepsis by Modulating Immunometabolism Upstream of PKM2
نویسندگان
چکیده
منابع مشابه
PKM2-dependent glycolysis promotes NLRP3 and AIM2 inflammasome activation
Sepsis, severe sepsis and septic shock are the main cause of mortality in non-cardiac intensive care units. Immunometabolism has been linked to sepsis; however, the precise mechanism by which metabolic reprogramming regulates the inflammatory response is unclear. Here we show that aerobic glycolysis contributes to sepsis by modulating inflammasome activation in macrophages. PKM2-mediated glycol...
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ژورنال
عنوان ژورنال: Molecular Medicine
سال: 2016
ISSN: 1076-1551,1528-3658
DOI: 10.2119/molmed.2015.00250